Publications by authors named "Z Kassam"
Background & Aims: Recurrent Clostridioides difficile infections (CDIs) remain common. While novel microbiome therapeutics gain approval, the efficacy of a full-spectrum, oral microbiome therapeutic is unknown. This study aimed to determine the safety and efficacy of CP101, an orally administered microbiome therapeutic, to restore a diverse microbiome and prevent recurrent CDI in a broad population.
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- - Crohn's disease (CD) can be tricky to diagnose because it causes inflammation that can skip areas of the intestines, particularly in the terminal ileum (TI), leading to potential mismanagement of the condition.
- - A study of 202 patients showed that 22.3% had inflammation in areas not seen during standard ileo-colonoscopy, with 24.5% having skip lesions mainly in the ileum, and strictures being missed in about 36.2% of cases without additional imaging.
- - The research highlights the importance of using cross-sectional imaging techniques, as they help identify more cases of active CD and stricturing disease that may go undetected with just ileo-colonoscopy.
Prevalence of stricturing, penetrating complications and extraintestinal manifestations in inflammatory bowel disease detected on cross-sectional imaging in a tertiary care setting.
United European Gastroenterol J
September 2024
Article Synopsis
- Inflammatory bowel disease (IBD) commonly leads to complications like strictures and extraintestinal manifestations (EIMs), but there is limited research on their prevalence.
- A study at two hospitals in London, Ontario, included 557 IBD patients who underwent imaging tests between 2010 and 2018, primarily using MR enterography (MRE).
- Results showed that about 40% of patients with Crohn's disease (CD) had strictures or fistulas, and 7% had detectable EIMs, with cholelithiasis being the most common EIM, indicating a significant burden of disease that requires targeted treatment options.
In 2023, the Canadian Society of Abdominal Radiology (CSAR) and Canadian Emergency, Trauma, and Acute Care Radiology Society (CETARS) received Canadian Association of Radiologists (CAR) member feedback that there was an unmet educational need for guidance in the imaging investigation of right lower quadrant (RLQ) pain. Members requested specific guidance on how to handle controversial scenarios including which test to order when, specifics of imaging protocols, and managing pregnant patients who have RLQ pain-all from a Canadian perspective. After conducting an exhaustive literature review, the working group agreed that a Canadian-specific set of guidelines was warranted.
View Article and Find Full Text PDFIn pancreatic adenocarcinoma, the difficult distinction between normal and affected pancreas on CT studies may lead to discordance between the pre-surgical assessment of vessel involvement and intraoperative findings. We hypothesize that a visual aid tool could improve the performance of radiology residents when detecting vascular invasion in pancreatic adenocarcinoma patients. This study consisted of 94 pancreatic adenocarcinoma patient CTs.
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