Publications by authors named "Z Kala"
Pancreas is a vital gland of gastrointestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies, with a 5-year survival rate of 11%. This poor prognosis is primarily attributed to the absence of early symptoms, rapid metastatic dissemination, and the limited efficacy of current therapeutic interventions.
View Article and Find Full Text PDFIntroduction: The management of patients with COVID-19 infection has placed great pressure on the healthcare systems around the world. The aim of this study was to investigate the impact of the COVID-19 pandemic on the treatment outcomes of patients with rectal cancer by comparing them to those of patients with the same diagnosis in the pre-pandemic period.
Methods: Retrospective data analysis of patients undergoing multimodal treatment for rectal cancer at the four university hospitals during the COVID-19 pandemic (2020-2021) and the 2-year pre-pandemic period (2018-2019).
Article Synopsis
- * The research focused on analyzing long non-coding RNAs (lncRNAs) in small extracellular vesicles (sEVs) from the blood serum of CRC patients, using two phases: an exploratory RNA sequencing phase and a subsequent validation phase with larger groups.
- * Results revealed 460 different RNA transcripts between CRC patients and healthy individuals, identifying three specific lncRNAs (NALT1, AL096828, and LINC01637) that were upregulated in CRC, paving the way for their potential use as diagnostic biomarkers in future studies.
Introduction: Minimally-invasive surgical methods have been becoming ever more common also in the segment of pancreatic surgery. The aim of this paper was to analyze the current state of minimally-invasive surgery in the Czech Republic and the justification and potential of implementing such procedures.
Methods: Analysis of high volume centers using healthcare providers´ and payers´ data.