Publications by authors named "Z K Otrock"

Zoonotic infections can result in life-threatening complications that can manifest with hemophagocytic lymphohistiocytosis (HLH)/cytokine storm syndrome (CSS). Bacteria constitute the largest group of zoonotic infection-related HLH cases. The growing list of zoonotic bacterial infections associated with HLH/CSS include Brucella spp.

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Background: Cold agglutinin disease (CAD) is relatively rare and has primarily been reported as retrospective case series.

Aim: We reviewed our experience with CAD to shed light on this disease.

Study Settings And Design: This was a retrospective review of all patients with CAD managed at our institution between 2007 and 2018.

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Article Synopsis
  • The study focused on identifying predictors of massive blood transfusion during orthotopic liver transplantation (OLT) to aid in better blood bank management.
  • Data was analyzed from 970 patients who underwent OLT between 2007 and 2017, highlighting that 12.3% experienced massive transfusions defined as receiving 10 or more units of packed red blood cells.
  • Key predictors of massive transfusion included factors like previous abdominal surgery, the patient’s hemoglobin level, MELD score, and the times related to cold and warm ischemia as well as overall operation duration.
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Sickle cell disease is one of the most common inherited hemoglobinopathies diagnosed in the United States. Patients often present with severe anemia, pain crises, infections, and vaso-occlusive phenomena. Complications of these disorders can lead to significant debilitating morbidity and mortality.

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Background: Graft-versus-host-disease (GVHD) is one of the rare complications following liver transplantation. We report on the efficacy and safety of extracorporeal photopheresis (ECP) in managing GVHD and hemophagocytic lymphohistiocytosis (HLH) after liver transplantation.

Case Report: The patient is a 63-year-old male with hepatitis B cirrhosis who underwent liver transplantation.

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