Synthesis, crystal structure and Hirshfeld surface analysis of hexa-aqua-nickel(II) bis-(4-hy-droxy-benzoate) dihydrate.

The title compound, [Ni(HO)](PHB)·2HO () (PHB = 4-hy-droxy-benzoate, CHO), was obtained by the reaction of NiCl, 4-hy-droxy-benzoic acid (PHBA) and mono-ethano-lamine in aqueous ethanol solution. The Ni ion is coordinated by six water mol-ecules and is located on an inversion center. The outer coordination sphere in the asymmetric unit comprises one PHB anion and one water mol-ecule, the compound is a salt and a hydrate consisting of three components.

[Copper metabolism in scleral tissue and possibilities of its correction in myopia].

Copper measurements in scleral tissue of 14 cadaveric emmetropic eyes and in 10 eyes with myopia of various degrees have shown a significant reduction of these levels in the equatorial and posterior segments of myopic sclera and abnormal distribution of copper in the tissue, this indicating disordered metabolism of this trace element. A method for drug correction of the detected disorder has been experimentally tried, consisting in administration under the Tenon's capsule of a copper coordination compound on a foam composition base, used for sclera-fortifying injections in progressive myopia. This resulted in elevation of scleral copper concentration, activization of collagen biosynthesis processes, and improvement of scleral tissue elasticity.