[The effect of metronidazole on the radiosensitivity of cancer of the uterine cervix].

A comparative study of the effect of rectal administration of metronidazole on radiosensitivity of cervical cancer with relation to tumor sizes and a Hb level was conducted. The effect of a direct tumor reaction on survival was investigated. Rectal administration of metronidazole proved to be effective in large tumor sizes and a low Hb level.

[Intratumoral and parametric administration of metronidazole in the radiotherapy of cancer of the cervix].

The paper is concerned with analysis of the results of radiation therapy of cervical cancer and intratumoral administration of metronidazole (124 patients with tumors, Stage IIB and III). At the end of the treatment, complete tumor regression in the intervention group (with metronidazole) was noted in 91% (irrespective of a stage of disease), in the control group (without metronidazole)--in 51% of the patients.

[Hemoglobin level--a prognostic factor of the effectiveness of metronidazole in radiotherapy of cancer of the cervix uteri].

A clinical trial was performed in 339 patients with Stages IIB, IIIB cervical carcinoma to test the effect of radiotherapy in combination with metronidazole. When the overall material was evaluated, no significant difference in the local clearance rate of tumors in metronidazole-treated and untreated patients was revealed. However, when the case material was subdivided into a group of anemic patients (hemoglobin less than 120 g/l) and a group of patients with normal hemoglobin levels (hemoglobin greater than 120 g/l) the data indicated that metronidazole therapy improved significantly the results in the anemic patients.