The impact of ciliary length on the mechanical response of osteocytes to fluid shear stress.

Background: Osteocytes are crucial for detecting mechanical stimuli and translating them into biochemical responses within the bone. The primary cilium, a cellular 'antenna,' plays a vital role in this process. However, there is a lack of direct correlation between cilium length changes and osteocyte mechanosensitivity changes.

Fault diagnosis method of rolling bearing based on SSA-VMD and RCMDE.

To address the limitations of weak information extraction of rolling bearing fault features and the poor generalization performance of diagnostic methods, a novel method was proposed based on sparrow search algorithm (SSA)-Variational Mode Decomposition (VMD) and refined composite multi-scale dispersion entropy (RCMDE). Firstly, SSA optimized the key parameters of VMD to decompose the fault signal. The time-frequency domain comprehensive evaluation factor algorithm was then employed to select the sensitive intrinsic mode function (IMF) components for reconstruction.

The effect of molecular chaperone mediated autophagy on ApoE expression in retinal pigment epithelial cells: Molecular structure and protein action mechanism.

Chaperone mediated autophagy (CMA) represents a specialized mechanism of lysosomal protein breakdown, playing a crucial role as a metabolic pathway that helps to regulate and sustain cellular and systemic physiological equilibrium. Within the CMA process, proteins that contain sequences similar to KFERQ are specifically identified by the heat shock cognate protein 70. These proteins are then chaperoned to the lysosomes for subsequent degradation, a process facilitated by the lysosome associated membrane protein 2A.

Observation of the Generalized Kerker Effect Mediated by Quasi-Bound States in the Continuum.

The generalized Kerker effect (GKE) arising from the interference of high-order multipoles has attracted more interest due to its direct correlation with various functionalities in nanophotonics. The realization of the GKE at oblique incidence is highly desired yet remains underexplored. Herein, we report the experimental observation of the GKE by leveraging quasi-bound states in the continuum (QBICs) supported by a silicon metasurface.

Multi-level Hierarchical Structure Analysis of Influencing Factors of Coal Mine Managers' Blame Avoidance Behavior.

Background: In the Chinese coal industry, widespread blame avoidance behavior (BAB) greatly impacts coal mine accidents. Therefore, it is necessary to stop the BAB of coal mine managers and raise the management level of coal mine enterprises for the safe development of Chinese coal industry.

Methods: Based on the semi-structured interviews and questionnaire surveys (20 middle-level managers in coal mines), this paper used the Grounded Theory and Nvivo Software qualitative research methodology to open, spindle, and selectively encode the interview data.