Publications by authors named "Z Jian-Hua"
Article Synopsis
- Aging negatively impacts memory and synaptic function due to disrupted calcium balance, primarily from overactive voltage-gated calcium channels (VGCC).
- In older mice, reduced levels of the AMPAR regulatory protein TARPγ8 correspond to lower CaMKIIα activity and cognitive decline, suggesting TARPγ8 is critical for memory and synaptic transmission.
- By inhibiting VGCC, researchers found that TARPγ8 and CaMKIIα levels increased in aged mice, and introducing human TARPγ8 in the hippocampus improved memory, highlighting its potential as a target for addressing age-related cognitive issues.
Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation.
Basic Clin Pharmacol Toxicol
March 2017
Inhaled budesonide and salbutamol represent the most important and frequently used drugs in asthmatic children during acute exacerbation. However, there is still no consensus about their resulting metabolic derangements; thus, this study was conducted to determine the distinct metabolic profiles of these two drugs. A total of 69 children with asthma during acute exacerbation were included, and their serum and urine were investigated using high-resolution nuclear magnetic resonance (NMR).
View Article and Find Full Text PDFAim: This study aims to investigate and evaluate the efficacy and safety of early enteral nutrition (EN) in maintaining and improving the postoperative nutritional status in patients undergoing esophagectomy.
Methods: A randomized, controlled clinical trial was conducted in 120 adult patients with esophageal cancer and undergoing esophagectomy. Patients were randomly divided into two groups receiving either EN (N.
A human serum albumin and Thymosin α1 (HSA-Tα1) fusion protein was designed and over-expressed in Pichia pastoris. To purify the fusion protein, a new native preparative electrophoresis system that involved a modified device with a sample receiving chamber, and an assay method with Coomassie Blue G-250 tracing the collection of the protein of interest. In this device, two gels were run in parallel: native vertical collecting polyacrylamide gel electrophoresis (PAGE) and native vertical tracing PAGE.
View Article and Find Full Text PDFArticle Synopsis
- Overexpression of the RASSF1A gene reduces growth in human gastric cancer SGC7901 cells, but the exact mechanisms are unclear.
- Using techniques like 2-D gel electrophoresis and MALDI-TOF MS, researchers identified 35 protein spots influenced by RASSF1A, with 10 up-regulated and 25 down-regulated.
- The study found that RASSF1A increased the expression of Galectin-1 and other proteins while inhibiting NF-κB activity, suggesting Galectin-1's potential role in RASSF1A signaling in these cancer cells.