[Has the pregnancy outcome of women with pregestational diabetes mellitus improved in ten years?].

Introduction: In spite of progress in medicine, studies from a number of countries indicate steadily increased risk of perinatal morbidity and mortality in the offspring of diabetic mothers. No data regarding the pregnancy outcome in women with diabetes mellitus type 1 and 2 (pregestational DM) have been published in the Czech Republic. The aim of the study was to evaluate the pregnancy course of women with pregestational DM and outcome of their offspring and to assess whether it has improved in ten years.

Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers.

Aim: To examine skin perfusion in dependency on insulinemia in healthy subjects.

Methods: All volunteers were informed in detail about the procedures and signed informed consent. The protocol of this study was approved by the ethical committee.

[Does physical activity produce clinically significant changes during discontinuation of insulin pump in type 1 diabetic patients?].

Introduction: Discontinuation of insulin pump treatment (CSII) before, during and after physical activity is a common practice among a number of patients. The aim of the study was to evaluate the course of insulinemia during a 3- hour insulin pump suspension and after consecutive insulin bolus administration, and additionally, to assess the effect of physical activity (mid intensity aerobic exercise).

Patient And Methods: We enrolled 12 patients with diabetes mellitus type 1 in the study (men, mean age 33.

Differences in skin microcirculation on the upper and lower extremities in patients with diabetes mellitus: relationship of diabetic neuropathy and skin microcirculation.

Introduction: During recent years, the role of microcirculation has received increasing attention especially for its potential pathogenic role in the development of diabetes complications, particularly diabetic foot syndrome. The aim of this study was to evaluate the differences in the skin microcirculatory reactivity on the upper and lower extremities (UE and LE, respectively) in the patient with type 2 diabetes mellitus (T2DM). We also evaluated the changes in the skin microcirculation independently of the individual test for peripheral diabetic neuropathy (DN) diagnosis (Semmes-Weinstein monofilaments, Bio-Thesiometer [Bio-Medical Instrument Co.