Publications by authors named "Z Jaidane"
Objectives: Determination of the superoxide dismutase (SOD), glutathione peroxidase (GPX) and the total antioxidant status (TAS) and evaluation of inflammation by the use of high sensitivity C reactive protein (hs-CRP) among Tunisian coronary diabetic patients.
Materials And Methods: We measured the erythrocyte GPX activity and the plasmatic TAS concentration by colorimetric methods, the apolipoproteins [ApoA1, ApoB], hs-CRP and the fibrinogen by immunonephelometry assays.
Results: TAS and GPX were significantly decreased among patients compared to the controls [TAS: 1,14 +/- 0,28 mmol/l vs 1,55 +/- 0,35 mmol/l, GPX: 59,32 +/- 10,72 U/gHb vs 149,19 +/- 30,95 U/gHb].
[Metachromatic leucodystrophy. Clinical, biological, and therapeutic aspects].
Ann Biol Clin (Paris)
September 2010
Article Synopsis
- Scholz's disease, also known as metachromatic leukodystrophy (MLD), is caused by the deficiency of the enzyme arylsulfatase A (ARSA), which is crucial for breaking down certain lipids in the nervous system.
- The accumulation of toxic sulfatides due to ARSA deficiency leads to various neurological problems, including mental retardation, blindness, and other nervous disorders.
- Diagnosis through genetic testing of the ARSA gene is recommended, as traditional enzyme activity tests do not accurately predict the severity of symptoms, while treatment mainly focuses on managing symptoms and attempting to restore enzyme function.
[Molecular analysis of the p.Asn 370 Ser mutation in Gaucher disease].
Pathol Biol (Paris)
March 2008
Gaucher disease is one of the most prevalent lysosomal disorders. In this present study, we report a diagnostic strategy of type 1 Gaucher disease. The application of combined methods in molecular biology allowed us to analyse the p.
View Article and Find Full Text PDF[Biochemical and molecular diagnosis of Gaucher disease in Tunisia].
Ann Biol Clin (Paris)
March 2008
Our study was carried out at a family from the Sahel (Tunisia). The father (index case) and his two children (son and daughter). The father beta-glucocerebrosidase (GCB) activity showing a deficit.
View Article and Find Full Text PDFUnlabelled: Mucopolysaccharidosis type I (MPS I) is a lysosomal disease due to mutations in the gene encoding alpha-l-iduronidase (IDUA) leading to variable clinical phenotypes with progressive severe organomegaly, bone and neurological involvement in the most severe forms. The aim of our study was to propose in Tunisia a strategy of molecular and prenatal diagnosis of the MPS I.
Population And Methods: Our study was carried out on 8 MPS I patients recruited from different Tunisian regions and issued from 5 unrelated families.