Identification and validation of five ferroptosis-related molecular signatures in keloids based on multiple transcriptome data analysis.

Introduction: Keloids are a common skin disorder characterized by excessive fibrous tissue proliferation, which can significantly impact patients' health. Ferroptosis, a form of regulated cell death, plays a crucial role in the development of fibrosis; however, its role in the mechanisms of keloid formation remains poorly understood.

Methods: This study aimed to identify key genes associated with ferroptosis in keloid formation.

Precise Tailoring of Unprecedent Layered Perovskite-type Heterostructure Ferroelectric via Chemical Molecular Scissor.

Precise stacking of distinct two-dimensional (2D) rigid slabs to build heterostructures has renewed the portfolio of 2D materials, e.g., magic-angle graphene, due to the emergence of exotic physical properties.

Two-Dimensional Layered Germanium Iodide Perovskite Ferroelectric Semiconductors.

The discovery of ferroelectricity in two-dimensional (2D) semiconductors has opened a new and exciting chapter in next-generation electronics and spintronics due to their lattice-dimensionality-induced unique behaviors and fascinating functionalities brought by spontaneous polarization. The emerging layered halide perovskites with 2D lattices provide a great platform for generating reduced symmetry and low-dimensional ferroelectricity. Herein, inspired by the approach of reduced lattice dimensionality, a series of 2D layered germanium iodide perovskite ferroelectric semiconductors A2CsGe2I7 [where A = PA (propylammonium), BA (butylammonium) and AA (amylammonium)] was firstly developed, which demonstrates remarkable semiconducting features including narrow direct bandgap (~1.

Dual-modal radiomics ultrasound model to diagnose cervical lymph node metastases of differentiated thyroid carcinoma: a two-center study.

Objectives: To establish and validate a dual-modal radiomics nomogram from grayscale ultrasound and color doppler flow imaging (CDFI) of cervical lymph nodes (LNs), aiming to improve the diagnostic accuracy of metastatic LNs in differentiated thyroid carcinoma (DTC).

Methods: DTC patients with suspected cervical LNs in two medical centers were retrospectively enrolled. Pathological results were set as gold standard.

Desmoglein-2 was a novel cancer-associated fibroblasts-related biomarker for oral squamous cell carcinoma.

Background: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer with alarmingly high morbidity. The cancer-associated fibroblasts (CAFs) play a pivotal role in tumor development, while their specific mechanisms in OSCC remains largely unclear. Our object is to explore a CAFs-related biomarker in OSCC.