TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma.

: TFEB activation is associated with prolonged survival in LUAD patients, suggesting potential benefits of TFEB agonists in LUAD treatment. In this study, we identify ginkgetin (GK), derived from , as a natural TFEB agonist, which has demonstrated promising anticancer effects in our previous research. TFEB activation has been shown to promote GPX4 degradation, inducing ferroptosis; however, the specific E3 ligases, deubiquitinating enzymes (DUBs), and types of polyubiquitination chains involved remain unclear.

Patterns of HER2 expression and genomic correlates in lung cancer, with a focus on preanalytical variables impacting immunohistochemical staining results.

Aims: Fam-trastuzumab deruxtecan-nxki (T-DXd) was recently approved for advanced stage or metastatic solid tumours with human epidermal growth factor receptor 2 (HER2) immunohistochemical (IHC) 3+ staining. Data on HER2 IHC testing and knowledge of genomic correlates in lung cancer are scarce. This study analyses genomic characteristics of HER2-expressing tumours and addresses issues with preanalytical variables for lung cancer specimens.

Evaluation of the effectiveness and safety of preoperative drug elution balloon therapy in patients with elective tumor surgery and coronary heart disease: a retrospective clinical study : The best choice of PCI for patients with elective tumor surgery and CHD.

Background: The selection of percutaneous coronary intervention (PCI) regimen for patients undergoing elective tumor surgery with coronary heart disease(CHD) remains controversial.To evaluate the effectiveness and safety of using Drug Eluting Balloons (DEB) in study patients.

Methods: A retrospective study was conducted on 127 patients undergoing elective tumor surgery with CHD who received preoperative PCI treatment at the Fourth Hospital of Hebei Medical University from January 2022 to May 2023.

A Mannosylated peptidyl lipid CManDA doped into cytidinyl/cationic lipids efficiently delivers siG12Ss to lung cancer in vivo.

Gene therapy has attracted widespread attention in recent years, and one of the important delivery systems is the LNP. However, many LNPs have potential toxicity and accumulate in the liver. Here, we designed and synthesized a Gemini-type mannosylated peptidyl lipid called CManDA(M), which, in combination with the cytidinyl lipid DNCA(D) and the peptidyl lipid CLD(C) (D/50C/50M), could transfect siRNA (siG12S) into A549 cells to target and silence the KRAS gene.

Maternal Decision-Making in Non-Mother Caregiving Negotiation for Infants in Black-and-White Snub-Nosed Monkeys (Rhinopithecus bieti).

Allomaternal care, or caregiving by non-maternal individuals, is prevalent in primates, yet few studies have explored the role of maternal consent and decision-making during this process. This study introduces the concept of "non-mother caregiving negotiation", highlighting the mother's primary role in deciding on non-maternal caregiving. This study focuses on a semi-provisioned breeding band of black-and-white snub-nosed monkeys (Rhinopithecus bieti) in the Xiangguqing area of the Baimaxueshan National Nature Reserve.