Rationale and Design of the Prevail Global Trial Program Evaluating the Prevail Drug-Coated Balloon in Patients with In-stent Restenosis and De Novo Small Vessel Disease.

Background And Rationale: In-stent restenosis (ISR) remains the leading cause of treatment failure following percutaneous coronary intervention (PCI) with contemporary drug-eluting stents. Especially in small caliber coronary arteries, restenosis is common following PCI and represents a treatment challenge. Drug-coated balloons (DCB) are an attractive alternative to stents for treatment of both ISR and small vessel disease.

Smartphone accelerometers as tools to study the effect of socioeconomic disparities in neurosurgical outcomes: a multi-institutional retrospective analysis.

Objective: Smartphones and wearable devices can be effective tools to objectively assess patient mobility and well-being before and after spine surgery. In this retrospective observational study, the authors investigated the relationship between these longitudinal perioperative patient activity data and socioeconomic and demographic correlates, assessing whether smartphone-captured metrics may allow neurosurgeons to distinguish intergroup patterns.

Methods: A multi-institutional retrospective study of patients who underwent spinal decompression with and without fusion between 2017 and 2021 was conducted.

Emotions & Heart:Exploring the Impact of Negative Emotions on Cardiovascular Health.

Negative emotions can have a significant impact on individuals, which then influences their cardiovascular system. However, the underlying pathophysiological mechanisms and clinical implications of this association remain inadequately defined. A narrative review of pertinent literature was conducted to examine the pathophysiology, clinical manifestations, and treatment related to the interplay between emotions and conditions such as takotsubo cardiomyopathy, atherosclerosis, acute plaque rupture, and cardiac arrhythmias.

Monkeypox Vaccine Hesitancy Among Healthcare Workers in Pakistan.

Objective: This study aimed to investigate healthcare workers (HCWs) acceptance of the HMPXV vaccine in Pakistan and identify influencing factors.

Methods: A cross-sectional survey of 4257 HCWs assessed vaccine acceptance across demographics, ethnicity, marital status, specialty, medical conditions, and education. Logistic regression identified predictors of acceptance.

Impact of nurse-led educational intervention on nurse's knowledge about patient safety after cardiac catheterisation.

Objective: To assess the impact of educational intervention on nurse's knowledge related to patient safety after cardiac catheterisation in tertiary care settings.

Methods: The quasi-experimental study was conducted from October 2022 to May 2023 after approval from the ethics review board of Dow University of Health Sciences, Karachi, and comprised staff nurses working in cardiac catheterisation laboratory, cardiac care unit and allied departments of 4 tertiary care hospitals. After baseline assessment, those with knowledge score <70% were enlisted for educational intervention which was done in small groups and lasted about 120 minutes.