Publications by authors named "Z Illes"
Currently, there are limited therapeutic options for patients with non-active secondary progressive multiple sclerosis. Therefore, real-world studies have investigated differences between patients with relapsing-remitting multiple sclerosis, non-active secondary progressive multiple sclerosis and active secondary progressive multiple sclerosis. Here, we explore patterns and predictors of transitioning between these phenotypes.
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- Teriflunomide, a medication for multiple sclerosis (MS), is linked to a higher risk of developing hypertension compared to another MS treatment, dimethyl fumarate.
- A study involving nearly 5,000 adult patients over 10 years showed that hypertension events occurred significantly more in those on teriflunomide (40.6 per 1000 person-years) than in those on dimethyl fumarate (13.1 per 1000 person-years).
- The findings indicate that patients on teriflunomide are 2.8 times more likely to develop hypertension, with a concerning "number needed to harm" of 16 at 3 years and 9 at 5 years.
Objective: Anti-CD20 therapy is a highly effective treatment for multiple sclerosis (MS). In this study, we investigated MS-related changes in peripheral blood mononuclear cell (PBMC) subsets compared to healthy controls and longitudinal changes related to the treatment.
Methods: Multicolor spectral flow cytometry analysis was performed on 78 samples to characterize disease- and treatment-related PBMC clusters.
Background: Autoimmune encephalitis (AE) comprises a group of rare, severe neuroinflammatory conditions. Current biomarkers of neuroinflammation are often normal in AE which therefore can be difficult to rule out in patients with seizures, cognitive and/or neuropsychiatric symptoms. Cerebrospinal fluid (CSF) soluble CD27 (sCD27) and soluble B-cell maturation antigen (sBCMA) have high sensitivity for neuroinflammation in other neuroinflammatory conditions.
View Article and Find Full Text PDFResting-state functional magnetic resonance imaging (rs-fMRI) has been widely utilized to investigate plasticity mechanisms and functional reorganization in multiple sclerosis (MS). Among many resting state (RS) networks, a significant role is played by the salience network (SN, ventral attention network). Previous reports have demonstrated the involvement of osteopontin (OPN) in the pathogenesis of MS, which acts as a proinflammatory cytokine ultimately leading to neurodegeneration.
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