[Effect of chronic exposure to low doses of ionized radiation on embryonal development of the Japanese quail].

Experiments on Japanese quail embryogenesis on a background of chronic exposure to gamma- and neutron doses comparable with the doses of ionized radiation inside the orbital space stations Mir and ISS, and exploration vehicles gave evidence that permanent absorption of low gamma-doses (0,15 cgy/d) did not impact development of the Japanese quail embryos. On the contrary, the neutron dose of 200 microgy/d imparted by the neutron flux of 30 particles/cm2s was hazardous to embryos as it caused morphological disorders in 12% of embryos.

A multi-center blinded prospective study of urine neural thread protein measurements in patients with suspected Alzheimer's disease.

Objective: To investigate the utility of a clinical laboratory ELISA format assay that measures neural thread protein (NTP) in urine in the assessment of patients presenting with cognitive symptoms.

Design: A prospective blinded multicentered study.

Setting: Eight US specialty clinics for the evaluation of cognitive or memory disorder or dementia, including memory disorder and dementia clinics, neurology clinics, and psychiatry clinics, in 8 states.

[Peculiarities of eye morphogenesis in embryonic Japanese quails developed in microgravity].

This work is a part of comprehensive research into the effects of space flight on Japanese quail ontogenesis. Analysis of eye morphogenesis in the embryonic Japanese quails developed in microgravity discovered considerable deviations and abnormalities. Ocular abnormalities in the embryonic quail were mainly micro-ophthalmic and associated with disproportional growth of the pigmental epithelium and neural retina which resulted in plication and a broken sandwich structure of the retina.

[Computer modeling in the study of mechanism of catalytic activity and the structure of active site of glutamine(asparagine)ase. I. Pharmacophore models of glutamine(asparagine)ase substrates].

Glutamine(asparagine)ase catalyses desamidation of both L-glutamine and L-asparagine, and their D-isomers. In this study the two-pharmacophore models of main enzyme substrates and their hydrolysed analogues were design. The received models reflect two stage of substrate interaction with the enzyme active site.

[Influence of hypodynamia on organism of Japanese quail].

The present study is a part of a more comprehensive investigation of the spaceflight effects on ontogenesis of the Japanese quail. Reported are data about the effects of a 33-day immobilization on behavior, physiology and the reproductive function of these birds. As was revealed in the experiment, immobilization reduces the mass of the quail body and leads to a number of reversible disorders in the reproductive function including a sharp decrease in oviposition in females and disturbances in spermatogenesis in males.