Haematopoietic malignancies in zoo animals.

Myelogenous leukaemia was found in a Russell's viper, a Honduran milk snake, a marine toad, a Byrne's marsupial mouse and an African hedgehog. Lymphocytic leukaemia was present in a broad banded copperhead and an Indian lion. Visceral lymphomatosis was observed in a snowy owl.

Nonlysosomal cytoplasmic degradation.

Several types of cytoplasmic and nuclear inclusions represent stages in the process of non-lysosomal cytoplasmic degradation. Nonlysosomal degradation takes place in regions where cytoplasmic components are trapped and not accessible to primary and secondary lysosomes. Such trapping occurs within the lumina of the nuclear envelope and of endoplasmic reticulum in the form of inverted vesicles, within the nucleus, within mitochondria and within cavities formed by the process of topolysis in neutral lipid droplets.

Globular changes in cytomegaloviral inclusions after Ganciclovir treatment.

Ganciclovir treatment induced eosinophilic intranuclear globules and loss of DNA staining in pulmonary CMV-infected cells. Nuclear capsids contained ring-shaped cores. Cytoplasmic vacuoles contained altered, enveloped, mostly coreless viral particles.

Aortic dissection in a gorilla.

Autopsy findings in a 39-year-old male gorilla included aortic dissection, internal rupture of the aortic arch with axial direction of the tear, external rupture of the ascending aorta, cardiac tamponade, myocardial hypertrophy, cystic and basophilic degeneration of the aortic media, marked obesity, severe degenerative joint disease, focal glomerulonephritis, and widespread hemosiderosis.

Diffuse nodular hyperplasia and fibrosis of the liver in lead-poisoned mandrills.

Two sibling mandrills with clinical evidence of lead intoxication showed previously unreported hepatic alterations. The younger animal had high lead concentrations in blood, kidneys, and liver and characteristic intranuclear inclusions in renal tubules and hepatocytes. The liver showed diffuse nodular regenerative hyperplasia.