Publications by authors named "Z H Kareem"

In conjunction with the global trend towards sustainable industry, this review provides a summary of the research endeavors and efforts made in the field of exploiting eggshells in the production of hydroxyapatite (HA). HA is one of the most used biomaterials and has attracted considerable attention over the years towards biomedical applications. As the traditional production of HA from calcium and phosphorus chemical precursors synthetically has bottlenecks of being expensive, complex, time consuming, and results in a low biocompatible product, natural resources have become an attractive alternative option to synthesize HA, with trace elements providing a higher performance.

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Background: The supraorbital artery (SOA) originates from the ophthalmic artery in a superomedial aspect of the orbit, exiting through the supraorbital groove to emerge onto the forehead. The SOA has important neurosurgical considerations regarding different approaches and bypasses. The SOA is poorly described in the standard anatomical textbooks.

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Article Synopsis
  • Diabetic patients face high mortality rates and poor recovery from ischemic strokes, which is linked to immune suppression observed in studies of both humans and diabetic mice.
  • Low doses of naltrexone (LDN) have shown promise in improving health outcomes by enhancing immune responses through the release of β-endorphin, which helps balance inflammation.
  • In experiments with diabetic mice, LDN treatment post-stroke increased β-endorphin and opioid growth factor levels, reducing brain injury and promoting neuron recovery compared to untreated mice.
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The opioid growth factor (OGF) is an endogenous peptide that binds to the nuclear-associated receptor (OGFr), and plays a significant role in the proliferation of developing, renewing, and healing tissues. The receptor is widely expressed in a variety of organs, however its distribution in the brain remains unknown. In this study, we investigated the distribution of OGFr in different brain regions of male heterozygous (-/+ Lepr /J), non -diabetic mice and determined the localization of the receptor in three major brain cell types, astrocytes, microglia, and neurons.

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