Ascertaining the Environmental Advantages of Pavement Designs Incorporating Recycled Content through a Parametric and Probabilistic Approach.

Reclaimed asphalt pavement (RAP) is a widely used end-of-life (EoL) material in asphalt pavements to increase the material circularity. However, the performance loss due to using RAP in the asphalt binder layer often requires a thicker layer, leading to additional material usage, energy consumption, and transportation effort. In this study, we developed a parametric and probabilistic life cycle assessment (LCA) framework to robustly compare various pavement designs incorporating recycled materials.

Environmental judicature and firm productivity: Evidence from a quasi-natural experiment.

The impact of environmental governance on firm productivity has been widely discussed, but few studies have examined the function of environmental judicature. Using the establishment of environmental courts as a quasi-natural experiment, this paper examines the relationship between environmental judicature and firm productivity. Our findings show that environmental courts will reduce firm productivity in the short term, chiefly owing to the increased environmental violation costs, environmental reputation costs and environmental compliance costs.

PSC1, a basic/helix-loop-helix transcription factor controlling the purplish-red testa trait in peanut.

Seed color is a key agronomic trait in crops such as peanut, where it is a vital indicator of both nutritional and commercial value. In recent years, peanuts with darker seed coats have gained market attention due to their high anthocyanin content. Here, we used bulk segregant analysis to identify the gene associated with the purplish-red coat trait and identified a novel gene encoding a basic/helix-loop-helix transcription factor, PURPLE RED SEED COAT1 (PSC1), which regulates the accumulation of anthocyanins in the seed coat.

Discovery of First-in-Class FXR and HSD17B13 Dual Modulator for the Treatment of Metabolic Dysfunction-Associated Fatty Liver Disease.

Metabolic dysfunction-associated steatohepatitis (MASH) is a complex disease driven by diverse metabolic and inflammatory pathways. Farnesoid X receptor (FXR) is a promising target for MASH due to its role in bile acid and lipid metabolism, while HSD17B13 regulates liver lipid droplet homeostasis. However, the existing HSD17B13 inhibitors have several druglike property challenges due to the common phenolic structure, a key pharmacophore for the HSD17B13 inhibitor.

Selective Minimally Invasive Strategy for Acute Superior Mesenteric Artery Obstruction.

Objective: Acute mesenteric artery obstruction is a severe cause of acute mesenteric ischemia, associated with significant morbidity and mortality. However, there is limited guidance on choosing between traditional and minimally invasive techniques comprehensively. This study introduces a selective, minimally invasive strategy designed to improve the survival and prognosis of patients with acute superior mesenteric artery obstruction.