Mizoribine or Cyclophosphamide for Lupus Nephritis: A Randomized Clinical Trial.

Importance: Lupus nephritis is typically treated with intravenous cyclophosphamide, which is associated with serious adverse effects. Oral mizoribine may be an alternative for induction therapy of lupus nephritis. However, large-scale, long-term, randomized clinical studies of mizoribine are lacking.

HLA-DQB1*03:01 and risk of Hepatitis B virus-related hepatocellular carcinoma.

Background Aims: The human leukocyte antigen (HLA) locus is implicated in hepatocellular carcinoma (HCC) among chronic hepatitis B virus (HBV) carriers. We investigated associations of HLA variants, amino acid polymorphisms, zygosity, and evolutionary divergence (HED) with HBV-related HCC in Han Chinese and explored biological mechanisms.

Approach Results: We examined the associations of HLA variants (imputed 4-digit classical alleles and amino acid polymorphisms), zygosity, and HED with HBV-related HCC in a discovery set (706 HBV-related HCC cases, 6,197 chronic HBV carriers in Taiwan).

Machine Learning-Assisted Prediction and Control of Bandgap for Organic-Inorganic Metal Halide Perovskites.

Perovskite materials have wide application prospects in many fields due to their tunable and designable band gap characteristics. Machine learning has obvious advantages in quickly and effectively discovering new materials. However, noise interference within data sets frequently hinders the ability of traditional predictive and evaluative techniques to satisfy practical requirements.

The complete mitochondrial genome of Allen, 1923 and its phylogenetic analyses.

This study aimed to examine the complete mitogenome sequence of Allen, 1923 using polymerase chain reaction. The mitochondrial genome of is a circular double-stranded structure with a complete length of 17,517 bp. The mitochondrial genome of included 13 protein-coding genes, one control region, 22 tRNA genes, two rRNA genes, and one origin of L-strand replication.

3D bioprinting of prefabricated artificial skin with multicomponent hydrogel for skin and hair follicle regeneration.

The timely management of large-scale wounds and the regeneration of skin appendages constitute major clinical issues. The production of high-precision and customizable artificial skin via 3D bioprinting offers a feasible means to surmount the predicament, within which the selection of bioactive materials and seed cells is critical. This study is aimed at employing skin stem cells and multicomponent hydrogels to prefabricate artificial skin through 3D bioprinting, which enables the regeneration of skin and its appendages.