Scintimammography and single-photon emission computed tomography for postoperative image guidance for radiation treatment planning in breast cancer patients.

Purpose: To evaluate post-surgical tumor-metabolic regions outside of the computed tomography (CT)-defined volume for radiation therapy (RT) planning using functional imaging of scintimammography (SMG) ± single photon emission computerized tomography (SPECT) in breast cancer (BC) patients.

Methods: 62 operated high-risk BC females, mean age 50.45 years, underwent SMG±SPECT before RT planning.

[Occurrence of second and third malignant tumors in patients with gynaecological cancer].

Objective: The aim of our study was to evaluate the occurrence of multiple primitive malignant gynaecological tumours in the genital tract, breast or other organs. We assessed the relationship between these tumours and we tried to find the association between localization, histology and staging.

Materials And Methods: The records of patients with gynaecological and breast cancer were used for the period of 1990 till 2003.

Optimized polymerase chain reaction-based single-strand conformation polymorphism analysis of p53 gene applied to Bulgarian patients with invasive breast cancer.

During the last few decades a substantial amount of evidence has accumulated proving that the abrogation of the normal p53 pathway is a critical step in the initiation and progression of tumors. Decoding the genetic mechanisms involved in carcinogenesis requires screening for consistent genetic tumor alterations, including those concerning the p53 gene. Thus, practical, efficient, and inexpensive techniques for accurate determination of p53 mutational status are needed.

[Conservative therapy of I and II stage breast cancer--successful alternative to modified radical mastectomy].

A clinical trial was conducted at the Center's Clinic to compare breast conserving treatment (quandrantectomy + radiation) (BCT) with modified radical mastectomy (M). It included 190 patients with stage I-II carcinoma up to 30 mm (BCT with "negative margin"--122; M--68). All the patients had undergone full axillary dissection.