Sex differences in the association between composite dietary antioxidant index and hyperlipidemia: Insights from NHANES.

Background: Previous studies have shown that both the composite dietary antioxidant index (CDAI) and sex are strongly associated with a variety of cardiovascular diseases, but sex differences between CDAI and hyperlipidemia are unknown.

Objective: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) to investigate the sex differences between CDAI and hyperlipidemia.

Method: We calculated the CDAI of the six dietary antioxidants using data from NHANES, explored the relationship between CDAI and the prevalence of hyperlipidemia using multivariate logistic regression analysis, and analyzed for potential nonlinear associations using restricted cubic spline.

Neuronal TRPV1-CGRP axis regulates peripheral nerve regeneration through ERK/HIF-1 signaling pathway.

Severe trauma frequently leads to nerve damage. Peripheral nerves possess a degree of regenerative ability, and actively promoting their recovery can help restore the sensory and functional capacities of tissues. The neuropeptide calcitonin gene-related peptide (CGRP) is believed to regulate the repair of injured peripheral nerves, with neuronal transient receptor potential vanilloid type 1 (TRPV1) potentially serving as a crucial upstream factor.

Causal relationship between immune cells and heart failure: A Mendelian randomization study.

This study aimed to evaluate the causal effects of different immune cells on heart failure (HF) using Mendelian randomization (MR). Datasets for immune cell phenotypes and HF were obtained from European Bioinformatics Institute and FinnGen. Then, single nucleotide polymorphisms were screened according to the basic assumptions of MR.

Dihydroartemisinin ameliorates skeletal muscle atrophy in the lung cancer cachexia mouse model.

Introduction: Cancer cachexia (CC) is characterized by weight loss with specifically reduced skeletal muscles and adipose tissues in patients with late-stage cancer. Dihydroartemisinin (DHA), an effective antimalarial derivative of artemisinin, has been demonstrated to have anti-inflammatory and antitumor properties.

Materials And Methods: This study examined the effects of DHA on the Lewis lung carcinoma (LLC)-induced CC mouse model.