[Antibacterial activity of some trichomonacidal agents].

In vitro and in vivo antibacterial activity of metronidazole preparations was studied in comparison to that of nitazole in various dosage forms: solution, aerosol, suspension and suppository. The metronidazole preparations inhibited only anaerobic organisms and were efficient in experimental infections caused by them. Unlike the metronidazole preparations, the dosage forms of nitazole inhibited the growth not only of anaerobic organisms but also that of staphylococci and had a therapeutic effect on infections caused by these organisms.

[Experimental and clinical study of nitazol as an antibacterial drug in the complex treatment of peritonitis].

Antibacterial properties of the Soviet drug nitazol which is a derivative of imidazole were studied. It was shown that nitazol in a dose of 4-8 micrograms/ml was highly active against gram-negative nonsporulating anaerobes, gram-positive anaerobic cocci and spore-forming Clostridia spp. Unlike metronidazole, it was efficient against both standard and clinical strains of facultative anaerobes such as E.

[The effect of dexamethoxin on the integrity of cytoplasmic membrane in gram-positive and gram-negative microorganisms].

Decamethoxin is shown to be able to increase membrane permeability of Pseudomonas aeruginosa, Escherichia coli and Micrococcus lysodeikticus, that is confirmed by a loss of compounds with the absorption maximum at 260 nm by cells. Parallel with this the number of viable individuals has fallen and activity of dehydrogenases has been inhibited. The aspartate and alanine aminotransferase activity was not inhibited by decamethoxin and even increased.

[Antibacterial activity of nitazole and its use in combined treatment of appendicular peritonitis in children].

The experimental-clinical investigations have demonstrated the high effectiveness of the native preparation Nitazole against the Gram-negative non-spore-forming anaerobic bacteria, Gram-positive anaerobic cocci, spore-forming Clostridium, certain facultative anaerobes. This permits to recommend it for the use as an antibacterial preparation for the treatment of peritonitis in children.