Distinct network patterns emerge from Cartesian and XOR epistasis models: a comparative network science analysis.

Background: Epistasis, the phenomenon where the effect of one gene (or variant) is masked or modified by one or more other genes, significantly contributes to the phenotypic variance of complex traits. Traditionally, epistasis has been modeled using the Cartesian epistatic model, a multiplicative approach based on standard statistical regression. However, a recent study investigating epistasis in obesity-related traits has identified potential limitations of the Cartesian epistatic model, revealing that it likely only detects a fraction of the genetic interactions occurring in natural systems.

m6A methylation dynamically participates in the immune response against Vibrio anguillarum in half-smooth tongue sole (Cynoglossus semilaevis).

N6-methyladenosine (m6A) is the most prevalent RNA modification and a multifaceted regulator capable of affecting various aspects of mRNA metabolism, thereby playing important roles in numerous physiological processes. However, it is still unknown whether, when, and to what extent m6A modulation are implicated in the immune response of an economically important aquaculture fish, half-smooth tongue sole (Cynoglossus semilaevis). Herein, we systematically profiled and characterized the m6A epitranscriptome and transcriptome in C.

Diversity and Potential Metabolic Characteristics of Culturable Copiotrophic Bacteria That Can Grow on Low-Nutrient Medium in Zhenbei Seamount in the South China Sea.

Oligotrophs are predominant in nutrient-poor environments, but copiotrophic bacteria may tolerate conditions of low energy and can also survive and thrive in these nutrient-limited conditions. In the present study, we isolated 648 strains using a dilution plating method after enrichment for low-nutrient conditions. We collected 150 seawater samples at 21 stations in different parts of the water column at the Zhenbei Seamount in the South China Sea.

Comparative Study on Online Prediction of TP2 Rolled Copper Tube Wall Thickness Based on Different Proxy Models.

The wall thickness of the TP2 copper tube casting billet is not uniform after a three-roll planetary rotational rolling, which affects the wall thickness uniformity of the copper tube in the subsequent process. In order to study the influence of wall thickness at different positions of copper pipe after rolling on the wall thickness of copper pipe after joint drawing, an online ultrasonic test platform was used to measure the wall thickness of copper pipe after tying, and based on the test data, a finite element model of copper pipe billet was established, and the numerical simulation of joint drawing wall thickness was conducted. Based on the results of the ultrasonic testing experiment and finite element simulation, different neural network models were used to predict the joint tensile wall thickness with the data of the ultrasonic testing experiment as input and the results of finite element simulation as output.

Shallow-water Trapezioidea (Decapoda: Brachyura) from the South China Sea, including two new records, and notes on Tetralia glaberrima Herbst, 1790.

A collection of coral symbiotic crabs (Trapezioidea) from the South China Sea reports a total of 24 species, including 12 species of Trapeziidae (including one new record: Trapezia plana Ward, 1941), four species of Domeciidae, and eight species of Tetraliidae (including one new record: Tetralia brengelae Trautwein, 2007). Live color and mitochondrial cytochrome oxidase I (COI) sequence data of all species are provided.