Publications by authors named "Z G Demirtakan"
Background: Coronary microvascular dysfunction (CMD) is the leading cause of ischemia with no obstructive coronary arteries disease (INOCA) disease. Diagnosis of CMD relies on surrogate physiological indices without objective proof of ischemia.
Objectives: Intracoronary electrocardiogram (icECG) derived hyperemic indices may accurately and objectively detect CMD and reversible ischemia in related territory.
Article Synopsis
- The study aims to compare Type-1 and Type-4 coronary microvascular dysfunction (CMD), specifically looking at their characteristics in patients with non-obstructed coronary arteries (INOCA) and those who have undergone percutaneous coronary intervention (PCI).
- Both groups showed similar overall decreases in coronary flow reserve (CFR) and hyperemic ECG changes, but distinct differences in blood flow response were observed.
- The findings suggest that Type-1 CMD exhibits more significant microvascular dysfunction compared to Type-4 CMD following PCI, despite both types resulting in similar levels of ischemia in the heart muscle.
Objective: Bicuspid aortic valve (BAV) is the most common congenital heart defect. Ascending aorta dilatation is related to BAV- and hypertension (HTN)-associated aortopathy. The aim of this study was to investigate aortic elasticity, as well as aortic deformation of the ascending aorta, using strain imaging, and to evaluate the possible relationship of biomarkers, such as endotrophin and matrix metalloproteinase-2 (MMP-2), with ascending aorta dilatation in patients with BAV- or HTN-associated aortopathy.
View Article and Find Full Text PDFBackground: This study aimed to determine whether a high level of high-sensitivity troponin T (hsTnT) predicts a positive treadmill test in patients with suspected stable ischemic heart disease (SIHD).
Methods: In all, 366 patients with suspected SIHD were included in the study. We measured the serum hsTnT levels before the treadmill test.
Article Synopsis
- A study investigates how reperfusion following a heart attack affects the blood vessels in areas not directly damaged by the attack in patients undergoing primary percutaneous intervention (pPCI).
- Researchers monitored changes in blood flow and pressure in these non-injured vessels before and one hour after the procedure, finding significant decreases in blood flow velocity and increases in microvascular resistance after reperfusion.
- The findings suggest that injury to the microcirculation can spread to healthy heart regions, particularly when there is a larger area of infarction and greater microvascular damage in the affected vessel.