Publications by authors named "Z Frysak"

Introduction: Functioning pituitary adenomas lead to substantial morbidity and increased mortality associated with typical endocrine syndromes. Surgical therapy is an integral part of the management of these tumours. The aim of this study was to evaluate the results of surgical transnasal procedures in patients with functioning pituitary adenomas who underwent the surgery at the Department of Neurosurgery, University Hospital Olomouc.

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Article Synopsis
  • Pheochromocytomas and paragangliomas are rare neuroendocrine tumors linked to autonomic nerves, and this study uses advanced gene sequencing to analyze their cellular composition compared to normal adrenal tissues.* -
  • The research identifies seven distinct gene-expression subtypes of PCPG, correlating them with specific genetic mutations and clinical characteristics, particularly highlighting the role of hypoxia and neoangiogenesis in tumors with certain mutations.* -
  • The findings reveal that while the tumor cells show characteristics of mature chromaffin cells, some PCPG subtypes also exhibit early-stage chromaffin and neuroblast markers, and they suggest potential therapeutic targets like GPR139 for treatment.*
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Purpose: To evaluate laboratory and clinical results after unilateral adrenalectomy in patients with primary aldosteronism (PHA).

Methods: A cross-sectional analysis was performed using data from patients who underwent transperitoneal laparoscopic adrenalectomy for PHA, between January 2008 and December 2019. Surgical indications were based on adrenal venous sampling without ACTH stimulation.

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Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors arising from chromaffin cells of adrenal medulla or sympathetic or parasympathetic paraganglia, respectively. To identify new therapeutic targets, we performed a detailed membrane-focused proteomic analysis of five human paraganglioma (PGL) samples. Using the Pitchfork strategy, which combines specific enrichments of glycopeptides, hydrophobic transmembrane segments, and non-glycosylated extra-membrane peptides, we identified over 1800 integral membrane proteins (IMPs).

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