[THE ETIOLOGY OF VIRAL INFECTIONS UNDER TRANSPLANTATION OF KIDNEY AND ALGORITHM OF THEIR LABORATORY DIAGNOSTIC].

The article presents data of virology examination of recipients of kidney in respect of actual agents of viral infections--cytomegalovirus, Epshtein-Barr virus, viruses of human herpes simplex type I and II, virus of human herpes type VI, Varicella-zoster virus, parvovirus B19, adenoviruses and BK virus. The dynamics of development of infectious processes were analyzed for dominating viral infections during 12 months after organ transplantation. The etiologic structure of viral complications in recipients of kidney was identified.

[Specific clinical, epidemiological patterns and laboratory diagnostics of enterovirus infection in the Republic of Belarus].

The clinical and epidemiological patterns as well as the results of the laboratory verification of the outbreak of enterovirus infection (EVI) in Minsk during the period of summer-autumn, 2000, are presented. During this outbreak a variety of clinical forms were observed, the serous meningitis being prevalent (57.5%).

[Laboratory diagnostics of enterovirus cardiac infections].

Diagnostic efficacy of different markers of enterovirus cardiac infection (EVCI) has been evaluated. Testing of clinical samples from patients with myocarditis (n=50), dilatation cardiomyopathy (n=122), ischemic heart disease (n=34) and from healthy donors (n=50) revealed diagnostically significant markers in patients suspected for enterovirus cardiac infection: antienterovirus IgM in the patient's blood serum, the expression of viral proteins by myocardium cells and the presence of genome RNA and replicative intermediate in cardiac cells. The results obtained were used for developing up-to-date scheme of the EVCI diagnosis which included the data from the case history, the preliminary rapid diagnosis and the molecular biological study of the cardiac biopsies.

[Outbreak of enteroviral infection in Vitebsk during pollution of water supply by enteroviruses].

The conducted virologic, serological and molecular-and-biological investigations showed that virus Coxsakie B4, isolated from cerebrospinal fluid and rhinopharyngeal lavages of patients, was the main etiological agent, which caused mainly an outbreak of enterovirus infection in the city of Vitebsk in 2001. Coxsakie B4 viruses were found in 30% of samples by using the cultural method and in 76.9% of samples--by polymerase chain reaction (PCR) while carrying out the sanitary-and-virologic investigations in drinking water, including in infection foci.

[Experience in the use of chemical compounds for the primary identification and differentiation of enteroviruses].

Data on the usage of chemical inhibitors nifan and belvtazid, which possess a selective and antienteroviral effect, in the primary identification of enteroviruses and their differentiation into polio- and non-poliomyelytic ones isolated from human clinical materials or the environment by using the cell culture are presented in the article. The method is recommended for the practical use by the virology service in the diagnostics of enteroviral infections and in the identification of cytopathic agents isolated from the enviroment.