An antiserum to tumour angiogenesis factor: therapeutic approach to solid tumours.

Tumour angiogenesis factor (TAF) was extracted from mouse mammary adenocarcinoma (mma) and various human tumours. Its ability to induce neovascularisation was demonstrated using the mouse intradermal and the chick chorioallantoic membrane assays. Similar extracts from normal tissues fail to induce angiogenesis.