Publications by authors named "Z Erlic"
Background: Arginine infusion stimulates copeptin secretion, a surrogate marker of arginine vasopressin (AVP), thereby serving as a diagnostic test in the differential diagnosis of suspected AVP deficiency (AVP-D). Yet, the precise mechanism underlying the stimulatory effect of arginine on the vasopressinergic system remains elusive. Arginine plays a significant role in the urea cycle and increases the production of urea.
View Article and Find Full Text PDFArticle Synopsis
- Hypophysitis, a condition affecting the pituitary gland, occurs in up to 10% of patients receiving immune-checkpoint inhibitors (ICIs) for melanoma, with one-third showing no MRI abnormalities, leading to potentially dangerous delays in diagnosis.
- This study assessed the effectiveness of FDG PET/CT scans in detecting ICI-induced hypophysitis by comparing patients with the condition to an age- and sex-matched control group, utilizing the target-to-background ratio (TBR) of the pituitary gland.
- Results indicated that a TBR of around 2.4 can predict impending hypophysitis in melanoma patients on ICI treatment, with a demonstrated sensitivity of 72.7% and specificity of
Article Synopsis
- * The results showed that PRL patients had a higher incidence of obesity, diabetes, and lipid imbalances; notable correlations existed between PRL characteristics and variables like BMI and blood sugar levels, while follow-ups revealed reductions in tumor size and prolactin levels after treatment.
- * The study emphasizes the metabolic implications of PRLs and suggests the need for more standardized follow-up strategies, as inflammatory markers did not effectively predict patient outcomes or stratification.
Article Synopsis
- Endocrine hypertension (EHT) is associated with various hormonal conditions like pheochromocytoma, Cushing's syndrome, and primary aldosteronism, leading to unique metabolic changes compared to primary hypertension (PHT).
- A multicenter study of 263 patients analyzed the relationship between adrenal steroid levels and metabolomic alterations, revealing significant associations among different hormone levels and specific metabolites.
- The findings suggest that elevated cortisol, cortisone, and catecholamines are linked to distinct metabolic profiles in EHT, with catecholamines being particularly important in pheochromocytoma cases.
Article Synopsis
- Distinguishing between arginine vasopressin deficiency (AVP-D) and primary polydipsia (PP) is difficult, and there's a lack of comparative data on their psychopathological features.
- A study involving 82 participants used standardized questionnaires to assess anxiety, alexithymia, depression, and overall mental health, finding both AVP-D and PP patients exhibited significantly higher levels of these issues compared to healthy controls.
- The findings indicate that AVP-D and PP patients have similar psychological challenges, suggesting that careful interpretation of these characteristics is essential for accurate diagnosis.