[Synthesis of carbamoyl tetrahydro 1,4,2-dioxazines and evaluation of their activity against human immunodeficiency virus].

1,4,2-dioxazine derivatives were synthesized from B-uréidoxyalcools, and their 1H, 13C RMN and mass spectra were determined. Their activity against human immunodeficiency virus and their cytotoxicity were then evaluated. Whereas the derivatives had no effect on virus infectivity nor on reverse transcriptase activity, they unexpectedly enhanced host cell infection by both lymphotropic and macrophage-tropic virus strains.