[Zinc content in pancreatic islets in experimental diabetes induced by chelating agents].

The zinc content in microresected islets of rabbits, mice, rats, and guinea pigs was determined by atom-absorption spectrophotometry. The content was found to be highest in rabbits, and diabetes was induced in them by chelating agents easily. Injection of dithizone or 8-(p-toluenesulfonylamine) quinoline failed to induce diabetes mellitus in mice, rats, and guinea pigs.

[Effect of glibenclamide on the ultrastructure of the islands of Langerhans and their insulin content].

The ultrastructure of the pancreatic islets and insulin content in the beta-cells, revealed by histochemical technique after glybenclamide loading, was investigated in rats. Glybenclamide administration led to the loss in beta-cells of a greater portion of their hormone depot. Ultrastructurally, a significant development in all the organellae of the protein synthesizing apparatus was demonstrated, this testifying to a sharp rise of the hormone production.