Calorimetry-based profiling of blood plasma from colorectal cancer patients.

Background: Differential scanning calorimetry (DSC), a highly sensitive technique for resolving thermally-induced protein folding/unfolding transitions, recently was recognized as a novel tool for disease diagnosis and monitoring. To further elaborate this approach we have applied DSC in a study of blood plasma from patients with colorectal cancer (CRC) at different stages of tumor development and localization.

Methods: Blood plasma from patients diagnosed with CRC was analyzed by DSC.

[Extensive right-sided hepatectomy for a metastatic process in patients operated on for colonic carcinoma].

Proceeding from experience with a large number of liver resections performed for single or multiple metastases atypical in appearance, including left lobectomies, a description is presented of wide right-sided hemihepatectomy, done for the first time (13 May 1997) in the surgical clinic of the National Oncological Center. The intervention is undertaken because of two metastases in the liver subsequent to radical operation for carcinoma of the sigmoid colon. The single stages of the operation are likewise described.

[The tumor markers CEA and CA-19.9 in patients with colorectal carcinoma].

The levels of two tumor markers--CEA and CA-19.9 were repeatedly determined in 146 patients with histologically verified colo-rectal cancer and in 58 healthy controls. The normal CA-19.

[A combined method for treating metastases of colorectal carcinoma to the liver].

The method is a combination of operative treatment of metastases in the liver and regional intra-arterial chemotherapy. The indications for operative treatment of the underlying tumor, the metastases in the liver and the regional chemotherapy are pointed out. Two groups of patients with colorectal cancer and remote metastases in the liver are presented: one received surgical treatment alone, the other combined therapy.

[Sexual disorders in men following radical operations on the rectum for carcinoma].

This is the first study in Bulgaria of postoperative sexual disorders following radical surgical operations for rectal cancer. The study group comprised 64 patients. Six months after the operation only 15 (24.