Publications by authors named "Z Dostalova"
Article Synopsis
- Acute lymphoblastic leukemia (ALL) is the most common cancer in children, characterized by fusion genes that are crucial for risk assessment and targeted treatment.
- Current detection methods, like fluorescence in situ hybridization and polymerase chain reaction, have limitations in sensitivity, missing new fusion genes.
- A new simplified procedure using RNA CaptureSeq and a specialized bioinformatics pipeline successfully identified both known and new fusion genes in pediatric samples previously deemed negative, enhancing diagnostic accuracy and potential treatment outcomes.
Propofol acts as a positive allosteric modulator of γ-aminobutyric acid type A receptors (GABAARs), an interaction necessary for its anesthetic potency in vivo as a general anesthetic. Identifying the location of propofol-binding sites is necessary to understand its mechanism of GABAAR modulation. [(3)H]2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(phenylethyl)-1H-imidazole-5-carboxylate (azietomidate) and R-[(3)H]5-allyl-1-methyl-5-(m-trifluoromethyl-diazirynylphenyl)barbituric acid (mTFD-MPAB), photoreactive analogs of 2-ethyl 1-(phenylethyl)-1H-imidazole-5-carboxylate (etomidate) and mephobarbital, respectively, have identified two homologous but pharmacologically distinct classes of intersubunit-binding sites for general anesthetics in the GABAAR transmembrane domain.
View Article and Find Full Text PDFObjective: To establish the prevalence of risk factors for aortic dissection, such as bicuspid aortic valve, aortic coarctation and ascending aorta dilatation, in women with low-level 45,X/46,XX mosaicism undergoing an in-vitro fertilization (IVF) procedure.
Methods: The study group comprised 25 women with low-level 45,X/46,XX mosaicism (ranging from 3.3% to 10.
Gamma-aminobutyric acid type A receptors (GABA(A)Rs) are the most important inhibitory chloride ion channels in the central nervous system and are major targets for a wide variety of drugs. The subunit compositions of GABA(A)Rs determine their function and pharmacological profile. GABAA Rs are heteropentamers of subunits, and (α1)2 (β3)2 (γ2L)1 is a common subtype.
View Article and Find Full Text PDFAim Of The Study: To determine the prevalence of Chlamydia trachomatis infection in patients treated for infertility.
Study Type: A retrospective analysis.
Setting: Fertimed, infertility treatment center, Olomouc.