Design, Synthesis, and Biological Activity Evaluation of 5-Aryl-cyclopenta[]pyridine Derivatives.

Taking the natural product cerbinal as the lead compound, 30 novel 5-aryl-cyclopenta[]pyridine derivatives were designed and synthesized based on the previous bioactivity studies of the cyclopenta[]pyridines. The modification of the position-5 of compound was achieved by amination, bromination, and cross coupling using cerbinal as the raw material. The results of the bioactivity tests demonstrated that partial compounds exhibited superior activity against plant viruses compared to compound .

The highly allo-autopolyploid modern sugarcane genome and very recent allopolyploidization in Saccharum.

Modern sugarcane, a highly allo-autopolyploid organism, has a very complex genome. In the present study, the karyotype and genome architecture of modern sugarcane were investigated, resulting in a genome assembly of 97 chromosomes (8.84 Gb).

Association of Forced Expiratory Volume in 0.5s With All-Cause Mortality Risk in Adults.

Introduction: Previous studies have proposed forced expiratory volume in 0.5s (FEV) to determine health outcomes in infants and young children, but few studies exist in adults. This study aims to investigate the associations between FEV and all-cause mortality in adults.

Correlation between polygenic risk scores of depression and cortical morphology networks.

Background: Cortical morphometry is an intermediate phenotype that is closely related to the genetics and onset of major depressive disorder (MDD), and cortical morphometric networks are considered more relevant to disease mechanisms than brain regions. We sought to investigate changes in cortical morphometric networks in MDD and their relationship with genetic risk in healthy controls.

Methods: We recruited healthy controls and patients with MDD of Han Chinese descent.

Arthroscopic treatment of calcific tendinitis of the popliteal tendon: A case report.

Introduction And Importance: Calcific tendinitis occurring in the popliteal tendon is extremely rare and has rarely been reported in the past. This case describes a patient who underwent arthroscopic surgery to remove the calcification of the popliteal tendon and achieved satisfactory results after surgery, providing valuable evidence for the feasibility of arthroscopic treatment of calcific tendinitis of the popliteal tendon.

Case Presentation: The patient was a 55-year-old female who was admitted to the hospital due to right knee pain and limited mobility.