Publications by authors named "Z DeFilipp"
Article Synopsis
- * Researchers analyzed data from 450 patients, finding that 310 were classified as ultra-low risk (ULR) based on their rapid clinical response and low MAP scores, leading to significantly better outcomes.
- * Patients in the ULR group had higher response rates at day 28 and lower non-relapse mortality at six months, suggesting that careful monitoring can guide safer, more effective GVHD treatment strategies.
Article Synopsis
- * A study analyzing 667 bone marrow harvests between 1999 and 2021 found a 13% contamination rate, primarily from common skin bacteria, with male donors showing significantly higher contamination rates (18% vs. 6.8% for females).
- * The research is notable for being the largest single-center study to explore contamination rates and highlights male donor sex as a key factor, potentially due to differences in skin flora.
The objective of this meta-analysis (MA) was to evaluate the efficacy and safety of extracorporeal photopheresis (ECP) for the treatment of steroid-refractory chronic graft-versus-host disease (SR-cGvHD). A systematic literature review (SLR) was conducted according to PRISMA guidelines, followed by a feasibility assessment (FA) to assess potential between-study heterogeneity in the meta-analysis (MA). Random-effects MAs were performed for overall survival (OS), failure-free survival (FFS), overall response rate (ORR) and skin-specific response.
View Article and Find Full Text PDFTo examine activity of ibrutinib in steroid-refractory chronic GVHD (SR-cGVHD) after FDA approval, we conducted a multicenter retrospective study. Data were standardly collected (N=270 from 19 centers). Involved organs included skin (75%), eye (61%), mouth (54%), joint/fascia (47%), GI (26%), lung (27%), liver (19%), genital (7%), other (4.
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