Combination of PAMP-induced peptide signaling and its regulator SpWRKY65 boosts tomato resistance to Phytophthora infestans.

Late blight, caused by Phytophthora infestans (P. infestans), seriously compromises tomato growth and yield. PAMP-induced peptides (PIPs) are secreted peptides that act as endogenous elicitors, triggering plant immune responses.

CPA4 overexpression correlates with poor prognosis and tumor progression in endometrial cancer.

Background: The rise in endometrial cancer rates globally calls for advanced diagnostic methods and new biomarkers. CPA4, known for its role in cancer development, has not yet been studied in relation to endometrial cancer, making it a promising research avenue.

Methods: We analyzed CPA4's mRNA expression using data from TCGA and GEO databases and validated these findings with 116 clinical samples through immunohistochemical analysis.

Exploring the potential benefits of growth hormone co-treatment on embryo quality in IVF: a randomized controlled open-label trial.

Research Question: While growth hormone (GH) is hypothesized to potentially enhance embryo quality, results of current basic and clinical researches remain inconclusive. This study assesses the effect of GH supplementation on embryo quality and explores the relationship between baseline insulin-like growth factor-1 (IGF-1) levels and the efficacy of GH supplementation among Chinese patients undergoing in vitro fertilization (IVF).

Design: A randomized controlled Open-label trial was performed with 128 women experiencing poor embryonic development in IVF.

Schisandrin B exerts anti-colorectal cancer effect through CXCL2/ERK/DUSP11 signaling pathway.

Background: Schisandrin B (Sch B) is an active component in Schisandra chinensis exerting anti-cancer effect, but the mechanism is obscure. This study was designed to explore the mechanism of Sch B against colorectal cancer (CRC).

Method: Apparent experiments including cell proliferation, transwell, colony formation, etc.

General synthesis of covalent organic frameworks under ambient condition within minutes via microplasma electrochemistry approach.

Covalent organic frameworks (COFs) are typically synthesized using solvothermal conditions with high temperature and long reaction time (≥120 °C, >72 h). Herein, we report a general and rapid microplasma electrochemistry strategy to synthesize COFs under ambient conditions. A series of flexible imine-bond COFs with high-crystallinity were prepared in minutes via this method, which showed 1000-fold higher space-time yield than solvothermal method.