Metabolism of 4-14C-dehydroepiandrosterone and 4-14C-4-androstene -3, 17-dione by isolated cells of early human placenta.

The preparation of isolated cells was used for the study of the metabolism of 4-14C-dehydroepiandrosterone and 4-14C-4-androstene-3,17-dione in early human placenta. Free cells suspension converted dehydroepiandrosterone and 4-androstene-3,17-dione into estrone, estradiol-17beta and into C1[neutral steroids 4-androstene-3,17-dione and testosterone.

The effect of antibody on the migratory pattern of peritoneal macrophages.

51Cr-labeled peritoneal macrophages which interiorized sheep erythrocytes (SRBC) injected i.p. into syngeneic recipients accumulate in a typical fashion in different organs.

Inhibitory effect of alpha-globulins of different origin on the cell-mediated immune responses in mice.

alpha-Globulins prepared from different biological sources (human and bovine sera, mouse ascitic fluid, human ovarian cyst fluid) were separated by ion exchange chromatography on DEAE-cellulose into fractions A, B and C. Whereas fractions A and B had no immunosuppressive activity, fraction C injected into mice shortly before antigen administration, but not after, significantly inhibited the contact sensitivity to oxazolone. Single high doses were preferential over divided doses given on several occasions.