Publications by authors named "Z Chao"

Article Synopsis
  • Immune checkpoint therapies have revolutionized cancer treatment but face challenges like low response rates and drug resistance, highlighting the need for a better understanding of the tumor microenvironment (TME).
  • Recent studies show that biomechanical forces within the TME significantly impact immune responses and tumor progression, indicating that manipulating these forces could enhance immune activation against tumors.
  • The review discusses key biomechanical mechanisms, the role of the extracellular matrix, and potential clinical applications, aiming to provide insights for discovering new therapeutic targets.
View Article and Find Full Text PDF

To address the significantly elevated safety risks associated with construction workers' improper use of helmets and reflective clothing, we propose an enhanced YOLOv8 model tailored for safety wear detection. Firstly, this study introduces the P2 detection layer within the YOLOv8 architecture, which substantially enriches semantic feature representation. Additionally, a lightweight Ghost module is integrated to replace the original backbone of YOLOv8, thereby reducing the parameter count and computational burden.

View Article and Find Full Text PDF

Background: The tiller number is a key agronomic trait for increasing the yield potential of wheat ( L.). A number of quantitative trait loci (QTLs) and key genes controlling tillering have been identified, but the regulatory mechanisms remain unclear.

View Article and Find Full Text PDF

Despite the availability of multiple treatment options for breast cancer, challenges such as adverse events, drug resistance, and disease progression persist for patients. The identification of human epidermal growth factor receptor 2 (HER2) as an oncogenic driver in a subset of breast cancers, alongside the development of HER2-targeted therapies, has significantly improved the prognosis of HER2-amplified breast cancers. However, therapeutic options remain limited for HER2-overexpressing or HER2-negative breast cancers.

View Article and Find Full Text PDF