A whole-body imaging technique for tumor-specific diagnostics and screening of B7-H3-targeted therapies.

Background: B7-H3 or CD276 is notably overexpressed in various malignant tumor cells in humans, with extremely high expression rates. The development of a radiotracer that targets B7-H3 may provide a universal tumor-specific imaging agent and allow the noninvasive assessment of the whole-body distribution of B7-H3-expressing lesions.

Methods: We enhanced and optimized the structure of an affibody (ABY) that targets B7-H3 to create the radiolabeled radiotracer [68Ga]Ga-B7H3-BCH, and then, we conducted both foundational experiments and clinical translational studies.

Clinical Characteristics and In Vivo Confocal Microscopic Study in Candida Keratitis.

Purpose: To clarify the clinical and imaging characteristics of Candida keratitis using in vivo confocal microscopy (IVCM) for improved early diagnosis and management.

Methods: A retrospective study of 40 patients with Candida keratitis at Beijing Tongren Hospital from January 2015 to December 2023 was conducted. Data included demographics, risk factors, clinical assessments, lab tests, and IVCM images.

Trends in Colorectal Cancer Peritoneal Metastases Research: A Comprehensive Bibliometric Analysis.

Background: Colorectal cancer (CRC) stands as the third most prevalent malignancy globally and is recognized as the second leading cause of cancer-related mortality. Notably, nearly 50% of individuals diagnosed with CRC ultimately develop metastatic disease, with the peritoneum emerging as the second most frequent site for metastatic spread. Recent advancements in therapeutic frameworks have enhanced both survival rates and quality of life metrics for patients afflicted with colorectal cancer peritoneal metastases (CRCPM).

Research on the spatial-temporal distribution of three-dimensional carbon footprint in different urban agglomerations in China.

This study expands the original two-dimensional carbon footprint model into a three-dimensional model form. Introduce two indicators of carbon footprint depth (CF) and size (CF) to form a three-dimensional carbon footprint model (CF), which is used to respectively represent the occupation and consumption of natural capital reserves by human activities' carbon emissions. Based on the 3D carbon footprint model, this paper calculated the CF, CF, and CF for four different urban agglomerations of China (BTH, YRD, PRD, and CY) spanning from 2000 to 2017.

Discovery of selective ROCK2 inhibitors with free radical scavenging ability for the treatment of gouty arthritis.

ROCK inhibitors can inhibit IL-1β and NLRP3, and their therapeutic potential for osteoarthritis and rheumatoid arthritis has been confirmed, but their impact on gouty arthritis has not been reported yet. By hybridization the structure of Edaravone, a series of ROCK inhibitors with pyrazolone scaffold were designed and synthesized. RM-04 has acceptable selective ROCK2 inhibitory activity with an IC of 4.