Aerobic exercise prevents renal osteodystrophy via irisin-activated osteoblasts.

Renal osteodystrophy is commonly seen in patients with chronic kidney disease (CKD) due to disrupted mineral homeostasis. Given the impaired renal function in these patients, common anti-resorptive agents, including bisphosphonates, must be used with caution or even contraindicated. Therefore, an alternative therapy without renal burden to combat renal osteodystrophy is urgently needed.

Discovery of viruses and bacteria associated with swine respiratory disease on farms at a nationwide scale in China using metatranscriptomic and metagenomic sequencing.

Respiratory disease (RD) is a worldwide leading threat to the pig industry, but there is still limited understanding of the pathogens associated with swine RD. In this study, we conducted a nationwide genomic surveillance on identifying viruses, bacteria, and antimicrobial resistance genes (ARGs) from the lungs of pigs with RD in China. By performing metatranscriptomic sequencing combined with metagenomic sequencing, we identified 21 viral species belonging to 12 viral families.

High-resolution groundwater storage anomalies in the Middle and Lower Yangtze River Basin of China using machine learning fusion of in-situ wells, satellite gravity and hydrological model.

Groundwater plays a key role in the water cycle and is used to meet industrial, agricultural, and domestic water demands. High-resolution modeling of groundwater storage is often challenging due to the limitations of observation techniques and mathematical methods. In this study, two machine learning (ML) algorithms, namely random forest (RF) and artificial neural networks (ANNs), were employed to estimate groundwater level anomaly (GWLA) and groundwater storage anomaly (GWSA) with a 0.

Retinal oculomics and risk of incident aortic aneurysm and aortic adverse events: a population-based cohort study.

Background: The asymptomatic onset and extremely high mortality rate of aortic aneurysm (AA) highlight the urgency of early detection and timely intervention. The alteration of retinal vascular features (RVFs) can reflect the systemic vascular properties, and be widely used as the biomarker for cardiovascular disease risk prediction. Therefore, we aimed to investigate associations of RVFs with AA and its progression.

Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction.

Behavioral addictive disorders (BADs) have become a significant societal challenge over time. The central feature of BADs is the loss of control over engaging in and continuing behaviors, even when facing negative consequences. The neurobiological underpinnings of BADs primarily involve impairments in the reward circuitry, encompassing the ventral tegmental area, nucleus accumbens in the ventral striatum, and prefrontal cortex.