Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of sporoderm-broken spores of on improving HFD-induced diabetic nephropathy rats.

Diabetes mellitus (DM) is a major metabolic disease endangering global health, with diabetic nephropathy (DN) as a primary complication lacking curative therapy. Sporoderm-broken spores of (GLP), an herbal medicine, has been used for the treatment of metabolic disorders. In this study, DN was induced in Sprague-Dawley rats using streptozotocin (STZ) and a high-fat diet (HFD), and the protective mechanisms of GLP were investigated through transcriptomic, metabolomic, and network pharmacology (NP) analyses.

Study on transportation and stress distribution of the overburden rock of gob side entry with cutting top and unloading pressure.

In order to solve the problems of serious deformation and difficult support of roadway surrounding rock in the process of gob-side entry driving, taking 230,708 working face of Huopu Mine as the engineering background, the migration characteristics of overburden rock and the stress distribution of surrounding rock before and after roof cutting in the process of gob-side entry driving were studied by means of theoretical analysis, similar simulation test and field measurement. The results show that: ① the establishment of lateral suspension mechanical model analysis found that, with the increase of coal seam dip angle, the reduction of the coal pillar bearing capacity before and after cutting the top gradually decreases, the dip angle of coal seam is 30°, Compared with the reduction of coal pillar bearing capacity before roof cutting is 2164 KN; with the increase of the overburden rock caving angle, the reduction of the coal pillar bearing capacity before and after cutting the top increases continuously, the caving angle of overburden rock is 63°, Compared with the reduction of coal pillar bearing capacity before roof cutting is 2218 KN. ② After the implementation of roof cutting and cutting off the overhanging roof structure, the stress of the surrounding rock of the coal pillar gang in the roadway has significantly decreased by 18.

New strategy for the utilization of invasive species: A tert-butylhydroquinone electrochemical platform based on Solidago canadensis L.

Tert-butylhydroquinone (TBHQ) is a widely used synthetic phenolic antioxidant found in edible oils and other fried foods. Nevertheless, the excess use of TBHQ can reduce food quality and impact public health. In this paper, we reported the synthesis of a nanocomposite consisting of carbon and nitrogen co-doped nickel oxide (NiO-N/C-700), which was used to modify a pencil graphite electrode for the sensitive detection of TBHQ.

Autonomous Anticoagulation on a Biomimetic Al-Based Hierarchical Surface.

Studies targeting the blood repellency and autonomous anticoagulation of superhydrophobic (SH) surfaces are potentially valuable for their application in blood contact. The anticoagulation abilities and potential mechanisms of different SH surfaces urgently need to be revealed. In this study, a range of microprotrusion arrays on Al substrates with varying spacings via laser ablation through the utilization of organic adsorption and siloxane coupling reactions were fabricated.

Association between serum albumin and severe impairment of activities of daily living in patients with stroke: a cross-sectional study.

Purpose: The relationship between serum albumin levels and severe limitations in ADLs among stroke patients remains unclear. Specifically, the dose-response relationship between the two needs further exploration. This study aims to provide further results.