Robust Mechanically Interlocked Network Ionogels.

Ionogels have attracted considerable attention as versatile materials due to their unique ionic conductivity and thermal stability. However, relatively weak mechanical performance of many existing ionogels has hindered their broader application. Herein, we develop robust, tough, and impact-resistant mechanically interlocked network ionogels (IGMINs) by incorporating ion liquids with mechanical bonds that can dissipate energy while maintain structural stability.

Hyperthermia suppresses the biological characteristics and migration of chicken primordial germ cells.

Primordial germ cells (PGCs) play a crucial role in transmitting genetic information to the next-generation. In chickens, genetically edited PGCs can be propagated and subsequently transplanted into recipient embryos to produce offspring with desired genetic traits. However, during early embryogenesis, the effects of external conditions on PGC migration through the vascular system to the gonads have yet to be explored, which may affect the efficiency of preparing gene-edited chickens.

Successful retrieval of lower limbs artery bone cement embolization resulting from percutaneous vertebroplasty: A rare case report.

Percutaneous vertebroplasty (PVP) is a widely utilized minimally invasive technique originally developed for the treatment of vertebral compression fractures. It has since expanded to treat osteoporotic vertebral compression fractures, pathologic vertebral fractures resulting from primary or secondary spinal tumors, and traumatic spinal fractures. Despite its benefits, PVP is associated with significant complications, the most common of which is bone cement leakage.

CD4-Derived Double-Negative T Cells Ameliorate Alzheimer's Disease-Like Phenotypes in the 5×FAD Mouse Model.

Background: Alzheimer's disease (AD) is a debilitating neurodegenerative disorder that is difficult to predict and is typically diagnosed only after symptoms manifest. Recently, CD4 T cell-derived double-negative T (DNT) cells have shown strong immuno-regulatory properties in both in vitro and in vivo neuronal inflammation studies. However, the effectiveness of DNT cells in treating on AD are not yet fully understood.

Tendon-mimicking anisotropic alginate-based double-network composite hydrogels with enhanced mechanical properties and high impact absorption.

Tendons are anisotropic tissues with exceptional mechanical properties, which result from their unique anisotropic structure and mechanical behavior under stress. While research has focused on replicating anisotropic structures and mechanical properties of tendons, fewer studies have examined their specific mechanical behaviors. Here, we present a simple method for creating calcium-crosslinked alginate-based double-network hydrogels that mimics tendons by exhibiting anisotropic structure, high mechanical strength and toughness, and a distinctive "toe region" when stretched.