Berbamine inhibits Pseudorabies virus in vitro and in vivo.

Pseudorabies virus (PRV) is a significant pathogen that causes acute infectious diseases in pigs, resulting in considerable economic losses for the global pig industry. The lack of effective control measures and vaccines against the circulating variants of PRV highlights the pressing need for novel treatment strategies. In this study, a screening of a natural product library identified Berbamine as a promising compound that inhibits PRV replication, with a selectivity index of 17.

Gut Microbiota as Mediator and Moderator Between Hepatitis B Virus and Hepatocellular Carcinoma: A Prospective Study.

Background: The impact of gut microbiome on hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is unclear. We aimed to evaluate the potential correlation between gut microbiome and HBV-related HCC and introduced novel machine learning (ML) signatures based on gut microbe to predict the risk of HCC.

Materials And Methods: A total of 640 patients with chronic liver diseases or HCC were prospectively recruited between 2019 and 2022.

Potential ecological risk of microplastics contamination to environment in protect area lakes.

Microplastics (MPs) in freshwater have been extensively studied on a global scale. However, a deeper understanding is still required regarding the occurrence characteristics and ecological risks of MPs in protected area lakes(PAL). Here, the study investigated MPs pollution in PAL, outside protected areas lakes (OPAL), and ponds (OPAP) in the eastern Qinghai-Tibetan Plateau, and a comprehensive analysis was conducted comparing lakes or ponds from different income regions.

Enhancing tribological performance of electric vehicle lubricants: Nanoparticle-enriched palm oil biolubricants for wear resistance.

The transition to electric vehicles (EVs) calls for sustainable advancements in automotive lubricants, as traditional fossil-fuel-based products pose environmental challenges. Palm oil-based biolubricants enriched with nanoparticles present a promising eco-friendly alternative that meets the thermal and tribological demands of EVs. This paper aims to analyze the development of nanoparticle-enriched palm oil-based biolubricants, aimed at improving the sustainability and performance of electric vehicle (EV) lubrication systems.

CIP2A inhibitors TD52 and Ethoxysanguinarine promote macrophage autophagy and alleviates acute pancreatitis by modulating the AKT-mTOR pathway.

Background: Acute pancreatitis (AP) is a prevalent and serious condition within the digestive system, with approximately 20 % to 30 % of cases advancing to severe acute pancreatitis (SAP). During the initial phases of SAP, macrophages are activated in response to the substantial amounts of acinar cell contents and damage-associated molecular patterns (DAMPs) resulting from acinar cell destruction. Subsequently, activated macrophages release a significant array of pro-inflammatory factors that exacerbate the progression of SAP.