Publications by authors named "Z Benyo"
Long COVID (also known as post-acute sequelae of SARS-CoV-2 infection [PASC] or post-COVID syndrome) is characterized by persistent symptoms that extend beyond the acute phase of SARS-CoV-2 infection, affecting approximately 10% to over 30% of those infected. It presents a significant clinical challenge, notably due to pronounced neurocognitive symptoms such as brain fog. The mechanisms underlying these effects are multifactorial, with mounting evidence pointing to a central role of cerebromicrovascular dysfunction.
View Article and Find Full Text PDFAging remains the foremost risk factor for cardiovascular and cerebrovascular diseases, surpassing traditional factors in epidemiological significance. This review elucidates the cellular and molecular mechanisms underlying vascular aging, with an emphasis on sex differences that influence disease progression and clinical outcomes in older adults. We discuss the convergence of aging processes at the macro- and microvascular levels and their contributions to the pathogenesis of vascular diseases.
View Article and Find Full Text PDFArticle Synopsis
- The Semmelweis Study in Hungary aims to address the public health challenges of unhealthy aging in the EU by examining the factors that contribute to age-related diseases, particularly vascular cognitive impairment (VCI).
- The pilot study involved 49 participants aged 23 to 87, assessing cognitive performance and vascular health through various advanced imaging techniques and tests.
- The analysis showed a correlation between vascular health indices, age, and cognitive performance, suggesting that a better understanding of this relationship could lead to new insights on healthy aging.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are effective for treating metastatic melanoma, but about 50% of patients show poor responses, often linked to low HLA-DR levels in tumors.
- The study highlights how lysophosphatidic acid (LPA), abundant in melanoma, increases IL-10 release and negatively impacts HLA-DR expression through the LPAR1-DR6 pathway.
- A significant correlation was found between the expression of LPAR1, DR6, and IL-10 in melanoma tissues, suggesting this pathway may contribute to tumor cells' ability to evade immune detection and compromise ICI therapy effectiveness.