Feasibility of controlled nitric oxide generation ascorbate induced chemical reduction of nitrite ions.

Inhalable nitric oxide (iNO) is a lifesaving, FDA-approved drug to improve oxygenation in persistent pulmonary hypertension of the newborn. iNO also has many other applications in lung diseases owing to its vasodilatory and antimicrobial effects. However, its wider therapeutic application is often prohibited by the high cost and logistical barriers of traditional NO/N gas tanks.

Antimony centre in three different roles: does donor strength or acceptor ability determine the bonding pattern?

A set of antimony(III) compounds containing a ligand (Ar) with a pendant guanidine function (where Ar = 2-[(MeN)CN]CH) was prepared and characterized. This includes triorgano-Ar3Sb, diorgano-Ar2SbCl and monoorgano-ArSbCl2 compounds and they were characterized by H and C NMR spectroscopy and by single-crystal X-ray diffraction analysis (sc-XRD). The coordination capability of Ar3Sb and Ar2SbCl was examined in the reactions with either -[PdCl(CHCN)] or PtCl and complexes -[(κ-Sb,N-Ar3Sb)MCl] (M = Pd 1, Pt 2) and [(κ-N,Sb,N-Ar2SbCl)MCl] (M = Pd 3, Pt 4) were isolated, while their structures were determined by sc-XRD.

Heterogenic Genetic Background of Distal Arthrogryposis-Review of the Literature and Case Report.

Distal arthrogryposis (DA) is a skeletal muscle disorder that is characterized by the presence of joint contractures in various parts of the body, particularly in the distal extremities. In this study, after a systematic review of the literature, we present a case report of a non-consanguineous family. In our case, the first-trimester ultrasound was negative, and the presence of the affected mother was not enough for the parents to consent to us performing invasive amniotic fluid sampling.

Advanced Protocol for Molecular Characterization of Viral Genome in Fission Yeast ().

Fission yeast, a single-cell eukaryotic organism, shares many fundamental cellular processes with higher eukaryotes, including gene transcription and regulation, cell cycle regulation, vesicular transport and membrane trafficking, and cell death resulting from the cellular stress response. As a result, fission yeast has proven to be a versatile model organism for studying human physiology and diseases such as cell cycle dysregulation and cancer, as well as autophagy and neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's diseases. Given that viruses are obligate intracellular parasites that rely on host cellular machinery to replicate and produce, fission yeast could serve as a surrogate to identify viral proteins that affect host cellular processes.