Publications by authors named "Z Belaid"
Article Synopsis
- - Targeting immune checkpoints like PD1 has improved survival for some cancer patients but many still experience relapse or do not respond to treatments.
- - Neuropilin-1 (NRP1) is identified as a potential immune checkpoint co-receptor that influences CD8 T cell activity in fighting tumors.
- - Research indicates that NRP1 enhances PD-1 activity and is linked to poorer outcomes in patients with metastatic melanoma treated with anti-PD1 therapies, suggesting it could be a target to improve treatment effectiveness.
Stem cell factor (SCF) and erythropoietin are strictly required for preventing apoptosis and stimulating proliferation, allowing the differentiation of erythroid precursors from colony-forming unit-E to the polychromatophilic stage. In contrast, terminal maturation to generate reticulocytes occurs independently of cytokine signaling by a mechanism not fully understood. Terminal differentiation is characterized by a sequence of morphological changes including a progressive decrease in cell size, chromatin condensation in the nucleus and disappearance of organelles, which requires transient caspase activation.
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- The study aimed to create an in vivo model to analyze interactions between hematopoietic cells and stromal cells by grafting murine bone marrow fibroblastic cells (MS-5) with hematopoietic cells into the kidney capsule of syngenic mice.
- The MS-5 stromal cells maintained their fibroblastic morphology and supported granulopoiesis when combined with bone marrow or isolated leukocytes, but differentiated into adipocytes when injected alone.
- The findings indicate that the MS-5 cells help sustain the survival of hematopoietic stem cells without inducing their differentiation, while also controlling the behavior of myeloid lineage cells.