Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.

Changes in immune and inflammatory responses may play a crucial role in the development and progression of atherosclerosis, as an autoimmune, chronic and progressive inflammatory disease. Immunological activity and vascular inflammation during atherosclerosis can be modulated by autoimmune responses against self-antigens, according to changeable risk factors (cholesterol, oxidized low-density lipoprotein (ox-LDL) in the vascular wall, fatty acids, etc.), and accompanied by accumulation of leucocytes and proinflammatory cytokines, which stimulate the transcription of matrix metalloproteinases (MMPs), whose concentration are increased in foam cell-rich regions.

Multiple sclerosis and cancers in Croatia--a possible protective role of the "Mediterranean diet".

Multiple sclerosis (MS) is an autoimmune disease triggered by a combination of genetic and environmental risk factors which are however individually insufficient to provoke the disease. Previous investigations studied the coexistence of cancer in MS patients, and only a few relations between the geographic distribution of MS and that of cancer. The aim of this research was to find an environmental link between the aetiology of MS and cancers in Croatia.

Assessment of psychological and social factors in adolescents risk behavior: questionnaire study.

Aim: To investigate the influence of psychological and social factors on health risk behaviors, such as smoking, alcohol and psychoactive drug consumption among adolescents and to determine the prevalence of consuming various psychoactive substances.

Methods: The survey was conducted among adolescents in the Primorsko-goranska County in Croatia in 2003. The prevalence of smokers, alcohol, and psychoactive drugs consumers and abstainers, with general and specific predictors for the development of risk behavior of 2,452 adolescents in Primorsko-goranska County was determined by means of valid self-reported questionnaires.