[Late results of strictly supervised treatment of patients with newly detected pulmonary tuberculosis].

The late results are analized, of a strictly supervised treatment of 160 patients with pulmonary tuberculosis, of the secondary bacilliferic type, recently discovered, between July 1974 and December 1976. The criterium for assessing the results was the bacteriologic examination. After the first year 144 of the patients became negative (90%), while 16 remained positive (10%).

Local production of proteins in normal human bronchial secretion.

Concentrations of albumin, IgG, IgA, IgM, alpha 1-acid glycoprotein, alpha 1-antitrypsin, alpha 2-macroglobulin, transferrin, haptoglobin, and coeruloplasmin were determined by radial immunodiffusion in the blood sera and bronchial washings of 8 patients without clinical, radiologic or bronchoscopic evidence of lung diseases. The local production of the proteins was calculated with a formula used by Deuschl and Johansson for the estimation of local synthesis of bronchial immunoglobulins. The formula was completed by a reduction factor established by the authors, based on their previous investigations.

[Studies of the proteins in normal bronchial secretion].

Parallel determinations were made, of 10 individual serum proteins and of proteins in the bronchial secretion obtained by aspiration from 8 subjects that did not show manifest bronchopulmonary disease. By application of the formula suggested by Deuschl and Johansson it was found that 37 percent of IgG, 84,5 percent of IgA, 48,9 percent of transferrins, 15,2 percent of alpha-1-anti-trypsin and 11,3 percent of ceruloplasmin present in the bronchial secretion are synthetised in the bronchial mucosa itself, while the rest occur as a result of diffusion from the blood. Acid alpha-1-glycoprotein and haptoglobin from the bronchial secretion originate in the blood.

[Studies of resumption of treatment with rifampin and ethambutol in patients with recurrent pulmonary tuberculosis].

The immediate and the late results are analyzed, of resumption of treatment with RMP and EMB in 50 patients with relapsing pulmonary tuberculosis that had not been treated with these drugs previously. After the first year of treatment negativation of the sputum by microscopy and culture was obtained in 45 of the patients, while 5 remained still positive. In the following two years 7 of the negative patients became positive again and finally 8 were solved completely and 4 became chronically ill.