Publications by authors named "Z Avaliani"
Article Synopsis
- * Out of 1,032 participants, 3.3% died during treatment and 8.7% after, with a median death time of 21 months post-TB treatment, particularly within the first 3 years.
- * Those with HIV co-infection had a significantly higher risk of post-TB mortality (almost four times higher) compared to those without HIV, highlighting the need for better care for TB patients with comorbidities.
Article Synopsis
- The study investigates the genetic relationship between Mycobacterium tuberculosis (MTB) cultures and diagnostic samples from TB cases, challenging the idea that culturing leads to loss of genomic diversity.
- Researchers developed an advanced workflow for sequencing sputum samples and performed a detailed bioinformatics analysis to examine discrepancies between sputum and culture results.
- Findings show a high agreement of 97% in genetic variants between sputum and culture pairs, suggesting that culturing reflects the genomic makeup of MTB accurately across various TB epidemic settings.
Background: While low body mass index (BMI) is associated with poor tuberculosis (TB) treatment outcomes, the impact of weight gain during TB treatment is unclear. To address this knowledge gap, we assessed if lack of weight gain is associated with all-cause mortality during and after TB treatment.
Methods: We conducted a retrospective cohort study among adults with newly diagnosed multi- or extensively drug-resistant (M/XDR) pulmonary TB in Georgia between 2009-2020.