Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster.

One of the major functions of programmed cell death (apoptosis) is the removal of cells that suffered oncogenic mutations, thereby preventing cancerous transformation. By making use of a Double-Headed-EP (DEP) transposon, a P element derivative made in our laboratory, we made an insertional mutagenesis screen in Drosophila melanogaster to identify genes that, when overexpressed, suppress the p53-activated apoptosis. The DEP element has Gal4-activatable, outward-directed UAS promoters at both ends, which can be deleted separately in vivo.

Pre-Pulse Inhibition of an escape response in adult fruit fly, .

Pre-Pulse Inhibition (PPI) is a neural process where suppression of a startle response is elicited by preceding the startling stimulus (Pulse) with a weak, non-startling one (Pre-Pulse). Defective PPI is widely employed as a behavioural endophenotype in humans and mammalian disorder-relevant models for neuropsychiatric disorders. We have developed a user-friendly, semi-automated, high-throughput-compatible light-off jump response PPI paradigm, with which we demonstrate that PPI, with similar parameters measured in mammals, exists in adults of this model organism.

FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor.

Optical insulation of the unit eyes (ommatidia) is an important prerequisite of precise sight with compound eyes. Separation of the ommatidia is ensured by pigment cells that organize into a hexagonal lattice in the Drosophila eye, forming thin walls between the facets. Cell adhesion, mediated by apically and latero-basally located junctional complexes, is crucial for stable attachment of these cells to each other and the basal lamina.

Dimensional Methods Used in the Additive Manufacturing Process.

It is a well-known fact that in the field of modern manufacturing processes, additive manufacturing (AM) offers unexpected opportunities for creativity and rapid development. Compared with classical manufacturing technologies, AM offers the advantages of reducing weight and improving performance and offers excellent design capabilities for prototyping and rapid sample manufacture. To achieve its full potential regarding cost, durability, material consumption, and rigidity, as well as maintaining competitiveness, there are several research directions that have not been explored.

Modern Dimensional Analysis Involved in Polymers Additive Manufacturing Optimization.

The paper aims to use Modern Dimensional Analysis () to study the polymers additive manufacturing optimization. The original part of the work is represented by the application of this nonconventional method in the field of polymers additive manufacturing. The laws of the model provide the complete sets of dimensionless variables, which cannot be offered by any of the classical methods (such as Geometric Analogy, Theory of Similarity, and Classical Dimensional Analysis).