Publications by authors named "Z Anwar"

Degradation of fenamates.

Profiles Drug Subst Excip Relat Methodol

January 2025

Fenamates are the most crucial non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain-related diseases. The clinically prescribed drugs of the fenamate group include mefenamic acid, tolfenamic acid, meclofenamic acid, flufenamic acid, and niflumic acid. Due to their widespread use, all these drugs are considered as the most common water and sewerage pollutants.

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This chapter presents an overall account of cyclodextrins (CDs) with a brief description of the history, classification, and properties of these macromolecules. CDs act as complexing agents for drugs to form CD-drug inclusion complexes by various techniques. These complexes lead to the modification of the physicochemical properties of drugs to make them more soluble, chemically, and photochemically stable, and less toxic.

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Collagenases are enzymes that break down collagen and are used in wound healing and treating various disorders. Currently, collagenase is commercially available in only ointment and injectable forms and is sensitive to various environmental factors. In the present study, different hydrogel formulations of collagenase have been prepared at pH 6.

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Article Synopsis
  • A reliable RP-HPLC method with UV detection was developed for the accurate measurement of Voriconazole in pure and gel formulations, using a 50:50 acetonitrile-water mobile phase and a flow rate of 1.0 ml/min.
  • The method demonstrated excellent linearity (correlation coefficient = 0.9999) and precision, with a percentage relative standard deviation (RSD) of less than 2.0.
  • Robustness was evaluated using variables like flow rate and pH; while flow rate significantly affected drug concentration, the method remained straightforward and suitable for daily quality control with a retention time of under 4 minutes.
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Riboflavin (RF) sensitized photooxidation of pyridoxine HCl (PD) in the pH range of 2.0-12.0 has been carried out under UV and visible irradiation in aerobic and anaerobic conditions.

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