Establishment and validation of predictive model of ARDS in critically ill patients.

Background: Acute respiratory distress syndrome (ARDS) is a prevalent complication among critically ill patients, constituting around 10% of intensive care unit (ICU) admissions and mortality rates ranging from 35 to 46%. Hence, early recognition and prediction of ARDS are crucial for the timely administration of targeted treatment. However, ARDS is frequently underdiagnosed or delayed, and its heterogeneity diminishes the clinical utility of ARDS biomarkers.

Hypothyroidism induced by excessive-iodine is associated in humans with altered hsa-miR-199a-5p/HIF-1α axis and thyroglobulin.

The adverse effect of excessive iodine intake has attracted extensive attention. However, the role of excessive iodine on hypothyroidism and detailed mechanism are not exactly known. Studies have shown that miRNAs are crucial to the occurrence and development of hypothyroidism.

A novel cytoprotective organ perfusion platform for reconstructing homeostasis of DCD liver while alleviating IRI injury.

Pump is a vital component for expelling the perfusate in small animal isolated organ normothermic machine perfusion (NMP) systems whose flexible structure and rhythmic contraction play a crucial role in maintaining perfusion system homeostasis. However, the continuous extrusion forming with the rigid stationary shaft of the peristaltic pumps can damage cells, leading to metabolic disorders and eventual dysfunction of transplanted organs. Here, we developed a novel biomimetic blood-gas system (BBGs) for preventing cell damage.

Identification and subcellular localization of the chaperonin NbCCTβ in Nosema bombycis.

Nosema bombycis, the causative agent of pebrine disease, poses a significant threat to the silkworm industry due to its negative impact on silkworm health and productivity. The chaperonin-containing tailless complex polypeptide (CCT) plays a crucial role in protein folding, and its β subunit (CCTβ) is essential for the proper folding of cytoskeletal proteins, such as actin and tubulin. In this study, we cloned and expressed the NbCCTβ gene from N.

A novel carbazole-pyrimidine-based dual mode fluorescent probe for detection of acidic and basic pH in biological systems.

pH balance is an important factor in regulating the internal environment of body and maintaining the normal physiological activities, but pH cannot be detected in vivo without damaging the tissue. It is important to develop a pH probe with low toxicity, high sensitivity and targeting of organelles. In this research, a novel carbazole-pyrimidine-based probe PKZP was designed from 2-hydroxyl-3-pinanone which was derived from natural monoterpene α-pinene for detecting both acidic and basic pH in vivo.